The Gunners are on a torrid run of form, having failed to win any of their last four games in all competitions, most recently being held to a 1-1 draw by Slavia Prague in the Europa League.
As things stand, Mikel Arteta’s side are 11th in the Premier League table, with chances of a top-six finish looking bleak.
But with eight games still left to be played, a good run can put them back in contention.
The Blades, meanwhile, are all but confirmed to go back down to the EFL Championship after what has been a disappointing campaign on so many levels.
Sheffield Utd Vs Arsenal Lineup
Sheffield Utd XI (3-5-2): Ramsdale, Egan, Ampadu, Stevens, Baldock, Lundstram, Norwood, Fleck, Osborn, McGoldrick, McBurnie
Arsenal XI (4-2-3-1): Leno, Chambers, Holding, Santos, Soares, Thomas, Xhaka, Saka, Ceballos, Pepe, Lacazette
Kick off is at 19:00 (GMT +1).